As galaxies assemble through
collisions and mergers, they grow bulges and activate supermassive black holes in their
nuclei, creating active galaxy nuclei. MIRI can probe obscured active galactic nuclei to
determine the evolution of supermassive black holes in the heyday of quasars at redshifts
of z ~ 2 - 2.5. (galaxy merger simulation by C. Mihos)
Perhaps 90% of the high redshift AGNs are heavily obscured (e.g. Gilli et al. 2000) Understanding AGN evolution requires understanding this dominant population, which can be identified from deep X-ray images with Chandra and XMM-Newton:

The following spectrum obtained with the short wavelength spectrometer on ISO shows this strong line because the Circinus galaxy is the site of an obscured active nucleus.

Even at a redshift of 2.5, the line is readily measurable to a luminosity of only twice that of the nearby obscured moderately luminous active nucleus in NGC 1068.
In addition, MIRI H alpha measurements can measure star formation rates in very young galaxies. A rate of 10 solar masses per year can be readily detected at a redshift of z ~ 10.